Light-Driven Three-Component Carbonylation of Aryl Halides Using Abundant Metal Carbonyl
Quansheng Mou, Tongyu Han, Mingxin Liu
Abstract
Carbonyl compounds are widely found in various pharmaceutical intermediates and synthetic precursors. Herein we report a simple light-driven three-component aryl halide process for synthesizing a variety of carbonylation products, utilizing Co 2 (CO) 8 as an abundant solid carbonyl source, in good to excellent yields. The products can easily be subjected to further functionalization in synthesis. Mechanism studies indicated that this reaction is enabled by aryl radical generation and the subsequent CO insertion, alkene insertion, and protonation process.
Topics & Concepts
CarbonylationChemistryArylHalideAlkeneProtonationComponent (thermodynamics)Combinatorial chemistrySurface modificationOrganic chemistryCatalysisPhotochemistryAlkylCarbon monoxideThermodynamicsPhysicsPhysical chemistryIonCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques