Cell morphology-guided <i>de novo</i> hit design by conditioning GANs on phenotypic image features
Paula Andrea Marin Zapata, Oscar Méndez‐Lucio, Tuan Le, Carsten Jörn Beese, Joerg Wichard, David Rouquié, Djork-Arné Clevert
Abstract
Cellular morphology can be used to guide the de novo design of small molecules inducing a desired phenotype.
Topics & Concepts
PhenotypeMorphology (biology)BiologyComputational biologyGeneticsGeneCell Image Analysis TechniquesComputational Drug Discovery MethodsViral Infectious Diseases and Gene Expression in Insects