Nitroreductase Increases Menadione-Mediated Oxidative Stress in<i>Aspergillus nidulans</i>
Yao Zhou, Hangya Lv, Haoxiang Li, Jingyi Li, Yunfeng Yan, Feiyun Liu, Wenliang Hao, Zhemin Zhou, Ping Wang, Shengmin Zhou
Abstract
Menadione is commonly used as an O 2 •− generator in studies into oxidative stress responses. However, the precise mechanism through which menadione mediates cellular O 2 •− generation, as well as the way in which cells respond, remains unclear.
Topics & Concepts
MenadioneAspergillus nidulansOxidative stressMicrobiologyOxidative phosphorylationNitroreductaseChemistryBiologyBiochemistryEnzymeGeneMutantAdvanced Nanomaterials in CatalysisRedox biology and oxidative stressSelenium in Biological Systems