A bifurcation concept for B-lymphoid/plasmacytoid dendritic cells with largely fluctuating transcriptome dynamics
Keiki Nagaharu, Yasuhiro Kojima, Haruka Hirose, Kodai Minoura, Kunihiko Hinohara, Hirohito Minami, Yuki Kageyama, Yuka Sugimoto, Masahiro Masuya, Shigeru Nii, Masahide Seki, Yutaka Suzuki, Isao Tawara, Teppei Shimamura, Naoyuki Katayama, Hiroyoshi Nishikawa, Kohshi Ohishi
Abstract
fraction and preferential expression of LFA-1 in pDC-biased progenitors with a niche-like culture system. We provide a model of fluctuation-based differentiation, which reconciles continuous and discrete models and is applicable to other developmental systems.
Topics & Concepts
TranscriptomeDynamics (music)BiologyCell biologyBifurcationComputational biologyGeneticsEvolutionary biologyGeneGene expressionPhysicsAcousticsNonlinear systemQuantum mechanicsT-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Cell Function and Interaction