Direct Electrochemical Selenylation/Cyclization of Alkenes: Access to Functionalized Benzheterocycles
Xiaomei Cheng, Balati Hasimujiang, Zhongnan Xu, Haiping Cai, Guihong Chen, Guangquan Mo, Zhixiong Ruan
Abstract
A catalyst-free, environmentally friendly, and efficient electrochemical selenylation/cyclization of alkenes has been developed with moderate to excellent yields. This selenylated transformation proceeds smoothly and tolerates a wide range of synthetically useful groups to deliver diverse functionalized benzheterocycles, including iminoisobenzofuran, lactones, oxindoles, and quinolinones. Moreover, the present synthetic route could also be readily scaled up to gram quantity with convenient operation in an undivided cell.
Topics & Concepts
ChemistryElectrochemistryCombinatorial chemistryEnvironmentally friendlyTransformation (genetics)CatalysisOrganic chemistryPhysical chemistryGeneElectrodeBiologyEcologyBiochemistrySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods