Soluble antigens derived from Coxiella burnetii elicit protective immunity in three animal models without inducing hypersensitivity
Anthony E. Gregory, Erin J. van Schaik, Alycia P. Fratzke, Kasi Russell‐Lodrigue, Christina M. Farris, James E. Samuel
Abstract
challenge in three animal models without inducing hypersensitivity. An NMI-derived extract, Sol I, enhances protection further and outperforms the WCV gold standard. Collectively, these data represent a promising approach to design highly effective, non-reactogenic Q fever vaccines.
Topics & Concepts
Coxiella burnetiiQ feverAntigenVirologyReactogenicityMicrobiologyBiologyAvidityVirulenceImmunologyImmunityAntibodyImmunogenicityImmune systemGeneBiochemistryVector-borne infectious diseasesYersinia bacterium, plague, ectoparasites researchInsect and Pesticide Research