Cell senescence, the senescence-associated secretory phenotype, and cancers
Larissa Prata, Tamar Tchkonia, James L. Kirkland
Abstract
Cellular senescence is a cell fate caused by multiple stresses. A 2008 article in PLOS Biology reported a senescence-associated secretory phenotype that can promote inflammation and cancer, eventually enabling the development of senolytic drugs.
Topics & Concepts
SenescenceBiologyPhenotypeCell biologyInflammationSecretionCellCellular senescenceGeneticsImmunologyGeneBiochemistryTelomeres, Telomerase, and SenescenceNeutrophil, Myeloperoxidase and Oxidative MechanismsAdvanced biosensing and bioanalysis techniques