Base- and metal-free visible-light driven site-selective α-C(sp<sup>3</sup>)–H functionalization reaction of glycine derivatives with hydroxamic acid derivatives
Shiyun He, Hongying Fan, Xue Zhang, Meiling Ye, Jian Chen, Jinyu Hou, Tianle Huang, Li Guo, Guanghui Lv, Yong Wu
Abstract
A visible-light-mediated radical–radical cross-coupling reaction between hydroxamic acid and N -phenyl glycine derivatives under base and metal free conditions is reported. A series of unnatural amino acids and peptides were obtained in good to excellent yields with good chemo-selectivity.
Topics & Concepts
ChemistrySurface modificationGlycineVisible spectrumBase (topology)MetalSelective surfaceCombinatorial chemistryHydroxamic acidPhotochemistryStereochemistryOrganic chemistryAmino acidBiochemistryMathematicsPhysical chemistryMathematical analysisPhysicsOptoelectronicsRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques