Low concentrations of ethylene bisdithiocarbamate pesticides maneb and mancozeb impair manganese and zinc homeostasis to induce oxidative stress and caspase-dependent apoptosis in human hepatocytes

Kilian Petitjean, Yann Verrès, Sébastien Bristeau, Catherine Ribault, Caroline Aninat, Christophe Olivier, Patricia Leroyer, Martine Ropert, Olivier Loréal, Olivier Hérault, Laurence Amalric, Nicole Baran, Bernard Fromenty, Anne Corlu, Pascal Loyer