Cellular Regulation of Macropinocytosis
Yumeng Wu, Xiao Hu, Z J Wei, Qiong Lin
Abstract
Interest in macropinocytosis has risen in recent years owing to its function in tumorigenesis, immune reaction, and viral infection. Cancer cells utilize macropinocytosis to acquire nutrients to support their uncontrolled proliferation and energy consumption. Macropinocytosis, a highly dynamic endocytic and vesicular process, is regulated by a series of cellular signaling pathways. The activation of small GTPases in conjunction with phosphoinositide signaling pivotally regulates the process of macropinocytosis. In this review, we summarize important findings about the regulation of macropinocytosis and provide information to increase our understanding of the regulatory mechanism underlying it.
Topics & Concepts
PinocytosisCell biologyEndocytic cycleBiologySignal transductionImmune systemGTPaseCarcinogenesisMechanism (biology)CellEndocytosisCancerImmunologyBiochemistryPhilosophyEpistemologyGeneticsCellular transport and secretionCalcium signaling and nucleotide metabolismErythrocyte Function and Pathophysiology