Antibacterial activity of 2-amino-3-cyanopyridine derivatives
I. G. Mamedov, Farid N. Naghiyev, Abel M. Maharramov, Owens Uwangue, Anne Farewell, Per Sunnerhagen, Máté Erdélyi
Abstract
New 2-amino-4-aryl-3-cyanopyridines were obtained by the three-component condensation of arylidenemalononitriles, malononitrile and (di)amine system or acetoacetanilide. Antibacterial activity of all synthesized compounds against the Gram-negative bacteria E. coli and the Gram-positive B. subtilis was tested, the only representative showed a substantial antimicrobial effect.
Topics & Concepts
MalononitrileChemistryAntibacterial activityAntimicrobialAmine gas treatingBacteriaArylGramCondensationOrganic chemistryCatalysisAlkylBiologyPhysicsGeneticsThermodynamicsPhenothiazines and Benzothiazines Synthesis and ActivitiesSynthesis and biological activitySynthesis of heterocyclic compounds