The autoimmune susceptibility gene, <i>PTPN2</i> , restricts expansion of a novel mouse adherent-invasive <i>E. coli</i>
Ali Shawki, Rocio Ramirez, Marianne R. Spalinger, Paul Ruegger, Anica Sayoc-Becerra, Alina N. Santos, Pritha Chatterjee, Vinicius Canale, Jonathan Mitchell, John C. Macbeth, Casey M. Gries, Michel L. Tremblay, Ansel Hsiao, James Borneman, Declan F. McCole
Abstract
, modulates the gut microbiome to protect against a novel pathobiont. This study generates new insights into gene-environment-microbiome interactions in IBD and identifies a new model to study AIEC-host interactions.
Topics & Concepts
BiologyMicrobiomeInflammatory bowel diseasePathogenesisGeneImmunologyMicrobiologyGeneticsPathogenDiseaseMedicinePathologyGut microbiota and healthCeliac Disease Research and ManagementHelicobacter pylori-related gastroenterology studies