Redundancy in Aromatic <i>O</i> -Demethylation and Ring-Opening Reactions in <i>Novosphingobium aromaticivorans</i> and Their Impact in the Metabolism of Plant-Derived Phenolics
Jose M. Perez, Wayne S. Kontur, Carson Gehl, Derek M. Gille, Yanjun Ma, Alyssa V. Niles, German E. Umana, Timothy J. Donohue, Daniel R. Noguera
Abstract
For lignocellulosic biorefineries to effectively contribute to reduction of fossil fuel use, they need to become efficient at producing chemicals from all major components of plant biomass. Making products from lignin will require engineering microorganisms to funnel multiple phenolic compounds to the chemicals of interest, and N. aromaticivorans is a promising chassis for this technology.
Topics & Concepts
Vanillic acidProtocatechuic acidSyringic acidDemethylationDioxygenaseLigninBiochemistryChemistryStereochemistryBiologyGallic acidOrganic chemistryEnzymeDNA methylationAntioxidantGeneGene expressionBiochemical and biochemical processesEnzyme-mediated dye degradation