Manganese‐Catalyzed Chemoselective Coupling of Secondary Alcohols, Primary Alcohols and Methanol
Jun Tang, Jingxi He, Sheng‐Yin Zhao, Weiping Liu
Abstract
Herein, we report a manganese-catalyzed three-component coupling of secondary alcohols, primary alcohols and methanol for the synthesis of β,β-methylated/alkylated secondary alcohols. Using our method, a series of 1-arylethanol, benzyl alcohol derivatives, and methanol undergo sequential coupling efficiently to construct assembled alcohols with high chemoselectivity in moderate to good yields. Mechanistic studies suggest that the reaction proceeds via methylation of a benzylated secondary alcohol intermediate to generate the final product.
Topics & Concepts
ChemoselectivityMethanolAlcoholPrimary (astronomy)ChemistryManganeseCatalysisPrimary alcoholBenzyl alcoholAlkylationOrganic chemistryCombinatorial chemistryAstronomyPhysicsAsymmetric Hydrogenation and CatalysisInnovative Microfluidic and Catalytic Techniques InnovationCatalytic C–H Functionalization Methods