Effect of ghrelin on glucose tolerance, gut hormones, appetite, and food intake after sleeve gastrectomy
Nora Hedbäck, Marie-Louise Dichman, Morten Hindsø, Carsten Dirksen, Nils Brun Jørgensen, Kirstine N. Bojsen‐Møller, Viggo B. Kristiansen, Jens F. Rehfeld, Bolette Hartmann, Jens J. Holst, Maria S. Svane, Sten Madsbad
Abstract
Ghrelin's effect on glucose tolerance and food intake following sleeve gastrectomy (SG) was evaluated. Acyl-ghrelin was infused during a mixed-meal and ad libitum meals before and 3 mo after surgery. Postprandial glucose concentrations increased during ghrelin infusions, both before and after surgery, while insulin production was inhibited. However, ad libitum meal intake did not differ during ghrelin administration compared with placebo. The decreased ghrelin concentration following SG may contribute to the glycemic control after surgery.