SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4 (CKAP4)
Kan Li, Liu Yao, Jin Wang, Hao Song, Yanhong Zhang, Xue Bai, Kai Zhang, Dongming Zhou, Ding Ai, Yi Zhu
Abstract
Although progressive respiratory failure is the primary cause of death in patients with COVID-19, thromboembolic complications further increased the mortality rates. Endothelial dysfunction, a pro-inflammatory and pro-coagulant state characterized by increased interaction with leukocytes and platelets, is reported to play a key role in COVID-19-associated thrombosis; 1 however, its underlying mechanism remains unclear.
Topics & Concepts
SecretionCytoskeletonSpike (software development)ThrombosisVon Willebrand factorActin cytoskeletonActinMedicineBiologyImmunologyCell biologyVirologyInternal medicineGeneticsCellPlateletEconomicsManagementCOVID-19 Clinical Research StudiesPhagocytosis and Immune RegulationCardiovascular Disease and Adiposity