Association between LXR-α and ABCA1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus in a Chinese Han Population
Peng Liu, Liang Ma, Hailing Zhao, Zhengri Shen, Xuefeng Zhou, Meihua Yan, Tingting Zhao, Haojun Zhang, Xinping Qiu, Ping Li
Abstract
We designed a case-control study and selected LXR-α rs7120118 C>T and ABCA1 rs2230806 A>G polymorphisms to determine the correlation between these polymorphisms and diabetic kidney disease (DKD) susceptibility in a Chinese Han population. Three hundred DKD patients and 346 type 2 diabetes mellitus (DM) patients without kidney disease were recruited. Our results showed that rs7120118 was associated with DKD (genotype, <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mi>P</a:mi> <a:mo>=</a:mo> <a:mn>.027</a:mn> </a:math> ; allele, <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" id="M2"> <c:mi>P</c:mi> <c:mo><</c:mo> <c:mn>.011</c:mn> </c:math> ). rs7120118 was associated with a higher risk of DKD under a dominant model adjustment by age and sex ( <e:math xmlns:e="http://www.w3.org/1998/Math/MathML" id="M3"> <e:mi>P</e:mi> <e:mo>=</e:mo> <e:mn>.015</e:mn> </e:math> ) and an additive model ( <g:math xmlns:g="http://www.w3.org/1998/Math/MathML" id="M4"> <g:mi>P</g:mi> <g:mo>=</g:mo> <g:mn>.040</g:mn> </g:math> ); rs2230806 was associated with a higher risk of DKD under an recessive model ( <i:math xmlns:i="http://www.w3.org/1998/Math/MathML" id="M5"> <i:mi>P</i:mi> <i:mo><</i:mo> <i:mn>.03</i:mn> </i:math> ); the combined effect of rs7120118 CC+rs2230806 GG genotype showed an association of DKD adjustment for age and sex ( <k:math xmlns:k="http://www.w3.org/1998/Math/MathML" id="M6"> <k:mi>P</k:mi> <k:mo>=</k:mo> <k:mn>.009</k:mn> </k:math> ). In subgroup analysis of patients without hypercholesterolemia, the rs2230806 genotype frequencies were different between the two groups ( <m:math xmlns:m="http://www.w3.org/1998/Math/MathML" id="M7"> <m:mi>P</m:mi> <m:mo>=</m:mo> <m:mn>.042</m:mn> </m:math> ). rs2230806 was associated with increased risk of DKD under a recessive model adjustment for age and sex ( <o:math xmlns:o="http://www.w3.org/1998/Math/MathML" id="M8"> <o:mi>P</o:mi> <o:mo>=</o:mo> <o:mn>.013</o:mn> </o:math> ) and an additive model ( <q:math xmlns:q="http://www.w3.org/1998/Math/MathML" id="M9"> <q:mi>P</q:mi> <q:mo>=</q:mo> <q:mn>.031</q:mn> </q:math> ). Our results suggest that LXR-α rs7120118 is significantly associated with a higher risk of DKD, and ABCA1 rs2230806 is significantly associated with a higher risk of DKD without hypercholesterolemia in Chinese Han individuals.