Au(I)-Catalyzed Regioselective Hydrofluorination of Propargylamines Using Aqueous HF
Hui Yang, Jie Wang, Can Jin, Xiaoqing Li, Xiangsheng Xu
Abstract
Gold-catalyzed regioselective hydrofluorination of alkynes using aqueous HF has been achieved by employing an amide directing group. For both aryl- and alkyl-substituted propargylamines, the fluorination occurred at the site distal to the amino group.
Topics & Concepts
RegioselectivityAmideAqueous solutionArylCatalysisChemistryAlkylCombinatorial chemistryHalogenationOrganic chemistryPolymer chemistryFluorine in Organic ChemistryCatalytic Alkyne ReactionsCatalytic C–H Functionalization Methods