Efficient synthesis of dipeptide analogues of α-fluorinated β-aminophosphonates
Marcin Kaźmierczak, Henryk Koroniak
Abstract
Herein, we present an efficient synthesis of dipeptide analogues of α-fluorinated β-aminophosphonates. Each step of the synthesis was optimized to provide excellent yields. Moreover, the absolute configuration of the obtained compounds was determined by X-ray analysis, which proved the stereochemistry that was proposed based on NMR studies.
Topics & Concepts
DipeptideChemistryCombinatorial chemistryStereochemistryAmino acidBiochemistryFluorine in Organic ChemistryChemical Synthesis and AnalysisOrganophosphorus compounds synthesis