Calcined chicken eggshell-derived biomimetic nano-hydroxyapatite as a local drug-delivery aid for doxycycline hyclate: characterization, bio-activity, cytotoxicity, antibacterial activity and <i>in vitro</i> release study
Mashrafi Bin Mobarak, M. Nahidul Islam, Fariha Chowdhury, Md. Najem Uddin, Md. Sahadat Hossain, Monika Mahmud, Umme Sarmeen Akhtar, Nazmul Islam Tanvir, Asma Rahman, Samina Ahmed
Abstract
release was studied under stirring in simulated body fluid (SBF). The DOXh release kinetics was evaluated, and it was found that the first-order model was the best fitted kinetic model describing the release of DOXh from the nHAp samples, except for nHAp100, which was best described by the Korsmeyer-Peppas model. The nHAp synthesized utilizing WCE showed excellent potential for biomedical application and can be used as a drug delivery agent for antibiotics, such as DOXh.
Topics & Concepts
ChemistryCytotoxicityDrug deliveryAntibacterial activityIn vitroNano-Characterization (materials science)DoxycyclineNanotechnologyNuclear chemistryMaterials scienceBiochemistryAntibioticsBiologyOrganic chemistryBacteriaComposite materialGeneticsBone Tissue Engineering MaterialsOrthopedic Infections and TreatmentsOrthopaedic implants and arthroplasty