A historical perspective on ACE2 in the COVID-19 era
Vivek Bhalla, Catherine A. Blish, Andrew M. South
Abstract
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Lessons learned from severe acute respiratory syndrome coronavirus (SARS-CoV) have facilitated a better understanding of the COVID-19 pandemic and efforts to develop targeted therapies. In particular, COVID-19 reminds us of the importance of the renin-angiotensin-aldosterone system (RAAS) in cardiovascular, pulmonary, and kidney physiology. After decades of RAAS research, we can apply this knowledge to better understand COVID-19 pathophysiology and to inform rigorous studies.
Topics & Concepts
MedicineCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Perspective (graphical)BetacoronavirusPeptidyl-Dipeptidase ACoronavirus InfectionsMEDLINEPandemicVirologyIntensive care medicineInternal medicineOutbreakBiochemistryDiseaseArtificial intelligenceInfectious disease (medical specialty)ChemistryRenin–angiotensin systemBlood pressureComputer scienceRenin-Angiotensin System StudiesClimate Change and Health ImpactsCOVID-19 Clinical Research Studies