Generation of self-replicating airway organoids from the cave nectar bat <i>Eonycteris spelaea</i> as a model system for studying host–pathogen interactions in the bat airway epithelium
Louisa Chan, Akshamal M. Gamage, Chee Wah Tan, Kai Sen Tan, Jing Liu, Douglas Jie Wen Tay, Randy Foo, Laurent Rénia, De Yun Wang, Lin‐Fa Wang
Abstract
ACE2 receptor being capable of mediating SARS-CoV-2 spike pseudovirus entry. This work provides critical model systems for assessing bat species-specific virus susceptibility and the reservoir likelihood for emerging infectious agents.
Topics & Concepts
BiologyAirwayOrganoidCiliumVirologyCell biologyMedicineSurgeryRespiratory viral infections researchBat Biology and Ecology StudiesViral gastroenteritis research and epidemiology