STK39 is a novel kinase contributing to the progression of hepatocellular carcinoma by the PLK1/ERK signaling pathway
Chengfei Zhang, Xiaoming Wang, Dan Fang, Ping Xu, Mo Xiao, Chao Hu, Alaa Abdelatty, Mei Wang, Haojun Xu, Qi Sun, Guoren Zhou, Junjun She, Jinglin Xia, Kam M. Hui, Hongping Xia
Abstract
Thus, our study uncovers a novel role of STK39/PLK1/ERK signaling axis in the progress of HCC and suggests STK39 as an indicator for prognosis and a potential drug target of HCC.
Topics & Concepts
MAPK/ERK pathwayCancer researchCell growthGene knockdownKinaseCell cycleSignal transductionApoptosisPLK1BiologyChemistryCell biologyBiochemistryMelanoma and MAPK Pathways14-3-3 protein interactionsCancer Mechanisms and Therapy