A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel
Chang Liu, Rebecca M. Reese, Simon Vu, Lionel Rougé, Shannon D. Shields, Satoko Kakiuchi-Kiyota, Huifen Chen, Kevin M. Johnson, Yu Shi, Tania Chernov-Rogan, Demi Maria Zabala Greiner, Pawan Bir Kohli, David H. Hackos, Bobby Brillantes, Christine Tam, Tianbo Li, Jianyong Wang, Brian S. Safina, Steve Magnuson, Matthew Volgraf, Jian Payandeh, Jie Zheng, Alexis Rohou, Jun Chen
Topics & Concepts
Covalent bondChemistryAgonistIon channelAntagonistCysteineBiophysicsLigand (biochemistry)Desensitization (medicine)Transient receptor potential channelPharmacologyReceptorBiochemistryBiologyOrganic chemistryEnzymeIon Channels and ReceptorsPhytochemicals and Antioxidant ActivitiesPostharvest Quality and Shelf Life Management