Transition-Metal-Catalyzed Stereo- and Regioselective Hydrosilylation of Unsymmetrical Alkynes
Shou‐Fei Zhu, Peng He, Mengyang Hu, Xinyu Zhang
Abstract
Abstract Alkyne hydrosilylation is one of the most efficient methods for the synthesis of alkenyl silicon derivatives and has been a hot topic of research for decades. This short review summarizes the progress in transition-metal-catalyzed stereo- and regioselective hydrosilylation of unsymmetrical alkynes. Topics are discussed based on different types of alkynes and the selectivities. 1 Introduction 2 Terminal Alkyne Hydrosilylation 2.1 β-E Selectivity 2.2 β-Z Selectivity 2.3 α-selectivity 3 Internal Alkyne Hydrosilylation 3.1 Aryl–Alkyl Acetylenes 3.2 Alkyl–Alkyl Acetylenes 3.3 Internal Alkynes with Polarized Substituents 4 Summary and Outlook
Topics & Concepts
HydrosilylationRegioselectivityChemistryAlkyneAlkylSelectivityArylCatalysisTransition metalMedicinal chemistryOrganic chemistryCombinatorial chemistryOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis