Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease
M.G. Deshmukh, Joseph A. Ippolito, Chunhui Zhang, Elizabeth A. Stone, R. Reilly, Scott J. Miller, William L. Jorgensen, Karen S. Anderson
Topics & Concepts
PharmacophorePerampanelPeptidomimeticChemistryProteaseActive siteContext (archaeology)Cysteine proteaseRational designStereochemistryCombinatorial chemistryComputational biologyBiochemistryPharmacologyEnzymeBiologyGeneticsAdverse effectPeptidePaleontologyComputational Drug Discovery MethodsSARS-CoV-2 and COVID-19 ResearchInfluenza Virus Research Studies