Mitochondria-targeting EGCG derivatives protect H9c2 cardiomyocytes from H<sub>2</sub>O<sub>2</sub>-induced apoptosis: design, synthesis and biological evaluation
Revathy Sahadevan, Anupama Binoy, Irene Shajan, Sushabhan Sadhukhan
Abstract
Mitochondrial-targeting EGCG derivatives, MitoEGCG n ( n = 4, 6) were able to effectively combat H 2 O 2 -induced oxidative stress and augment mitochondrial health by maintaining mitochondrial function and attenuating apoptosis in H9c2 cardiomyocytes.
Topics & Concepts
Oxidative stressApoptosisMitochondrionReactive oxygen speciesOxidative phosphorylationCell biologyFragmentation (computing)ChemistryDNA fragmentationMembrane potentialBiochemistryProgrammed cell deathBiologyEcologyAdvanced Nanomaterials in CatalysisTea Polyphenols and EffectsMitochondrial Function and Pathology