Human Aortic Stenotic Valve-Derived Extracellular Vesicles Induce Endothelial Dysfunction and Thrombogenicity Through AT1R/NADPH Oxidases/SGLT2 Pro-Oxidant Pathway
Sandy Hmadeh, Antonin Trimaille, Kensuke Matsushita, Benjamin Marchandot, Adrien Carmona, Fatiha Zobairi, Chisato Sato, Michel Kindo, Tam Hoang, Florence Toti, Kazem Zibara, Eva Hamade, Valérie B. Schini‐Kerth, Gilles Kauffenstein, Olivier Morel
Abstract
Pathological tissues release a variety of factors, including extracellular vesicles (EVs) shed by activated or apoptotic cells. EVs trapped within the native pathological valves may act as key mediators of valve thrombosis. Human aortic stenosis EVs promote activation of valvular endothelial cells, leading to endothelial dysfunction, and proadhesive and procoagulant responses.
Topics & Concepts
ThrombogenicityEndothelial dysfunctionExtracellular vesiclesExtracellularCell biologyMicrovesicleThrombosisEndothelial stem cellInflammationMedicineCardiologyChemistryInternal medicineMicrovesiclesBiochemistryBiologyIn vitromicroRNAGeneCardiac Valve Diseases and TreatmentsExtracellular vesicles in diseaseVenous Thromboembolism Diagnosis and Management