Synthesis and anticancer mechanisms of zinc(<scp>ii</scp>)-8-hydroxyquinoline complexes with 1,10-phenanthroline ancillary ligands
Ling-Qi Du, Tianyu Zhang, Xiaomei Huang, Yue Xu, Ming‐Xiong Tan, Yan Huang, Yuan Chen, Qi‐Pin Qin
Abstract
DQ1–DQ20 exhibit selective cytotoxicity to SK-OV-3/DDP. They inhibit cell growth via mitophagy pathways. Importantly, DQ6 displays high in vivo antitumor activity.
Topics & Concepts
ZincCytotoxicityCytotoxic T cellCisplatinApoptosisChemistryStereochemistryIn vitroPhenanthrolineMolecular biologyBiochemistryBiologyGeneticsCrystallographyOrganic chemistryChemotherapyMetal complexes synthesis and propertiesMetal-Organic Frameworks: Synthesis and ApplicationsLanthanide and Transition Metal Complexes