Exploring the target scope of KEAP1 E3 ligase-based PROTACs
Guangyan Du, Jie Jiang, Nathaniel J. Henning, Nozhat Safaee, Eriko Koide, Radosław P. Nowak, Katherine A. Donovan, Hojong Yoon, Inchul You, Hong Yue, Nicholas A. Eleuteri, Zhixiang He, Zhengnian Li, Hubert T. Huang, Jianwei Che, Behnam Nabet, Tinghu Zhang, Eric S. Fischer, Nathanael S. Gray
Topics & Concepts
Ubiquitin ligaseCereblonUbiquitinDNA ligaseDegronKEAP1Ubiquitin-Protein LigasesChemistryCell biologyComputational biologyBiologyBiochemistryTranscription factorGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis