Therapeutic effects of vitamin D and cancer: An overview
Jisha Elsa Varghese, Balamuralikrishnan Balasubramanian, Shanmugam Velayuthaprabhu, Thirunavukkarasu Velusamy, Rengasamy Lakshminarayanan Rengarajan, Easwaran Murugesh, Pappusamy Manikandan, Arun Meyyazhagan, Arumugam Vijaya Anand
Abstract
Abstract Since vitamin D's discovery, strenuous efforts to investigate its physiological exploit and deficiency on human health were done. Our body synthesizes fat‐soluble vitamin D when get exposed to sunlight. In recent years, experimental data indicate that sunlight exposure and an adequate level of circulating vitamin D can reduce the incidence of cancer. Several in vitro and in vivo studies also suggest vitamin D as a potentially valuable supplement for cancer treatment and prevention. Nevertheless, there need to be adequate clinical studies performed to substantiate the suppressive ability of vitamin D concerning cancer incidence. Thus, understanding the cellular mechanisms of vitamin D can be advantageous for preventing several chronic diseases. Consequently, this review concentrates on different studies that have been conducted to characterize the outcome of vitamin D in reducing cancer incidence and its medication by cellular progression mechanism.