Asymmetric organocatalytic (3 + 2) annulation of propargylic alcohols with indolylnaphthalenols: synergistic construction of axial and central chirality
Yan Xia, Meiwen Liu, Chenxiao Qian, Pengfei Li, Mingxin Dong, Wenjun Li
Abstract
Organocatalytic enantioselective construction of chiral spiro N , N -acetal carbon stereocenters and axially chiral 3-arylindoles has been achieved in one pot.
Topics & Concepts
StereocenterChemistryAnnulationEnantioselective synthesisChirality (physics)Axial chiralityOrganocatalysisAxial symmetryAcetalCatalysisStereochemistryCombinatorial chemistryOrganic chemistryPhysicsParticle physicsQuarkNambu–Jona-Lasinio modelChiral symmetry breakingQuantum mechanicsAxial and Atropisomeric Chirality SynthesisAlkaloids: synthesis and pharmacologyMolecular spectroscopy and chirality