Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation
Dianyu Chen, Yan Wang, Godhev K. Manakkat Vijay, Shujie Fu, Colt W. Nash, Di Xu, Danyang He, Nathan Salomonis, Harinder Singh, Heping Xu
Topics & Concepts
Somatic hypermutationAffinity maturationBiologyGerminal centerTranscriptomeOxidative phosphorylationSomatic cellGeneB cellbreakpoint cluster regionMolecular biologyCell biologyAntibodyGeneticsGene expressionBiochemistryT-cell and B-cell ImmunologyImmune Cell Function and InteractionCAR-T cell therapy research