Consistent Stool Metagenomic Biomarkers Associated with the Response To Melanoma Immunotherapy
Evgenii I. Olekhnovich, A. B. Ivanov, Anna A. Babkina, Arseniy A. Sokolov, Vladimir Ulyantsev, Dmitry E. Fedorov, Elena N. Ilina
Abstract
In this study, we put together a list of potentially the most beneficial bacteria that were associated with a responsiveness to melanoma immunotherapy. Another important result of this study is the list of functional biomarkers of responsiveness to immunotherapy, which are dispersed among different bacterial species. This result possibly explains the existing irregularities between studies regarding the bacterial species that are beneficial to melanoma immunotherapy. Overall, these findings can be utilized to issue recommendations for gut microbiome correction in cancer immunotherapy, and the resulting list of biomarkers might serve as a good stepping stone for the development of a diagnostic test that is aimed at predicting patients' responses to melanoma immunotherapy.