Inhibition of Inflammatory Response and Promotion of Osteogenic Activity of Zinc-Doped Micro-Arc Titanium Oxide Coatings
Haishui Sun, Yiming Yang, Lei Yu, Ke Liu, Yifan Fei, Chaoyang Guo, Yuqi Zhou, Jingzhou Hu, Lei Shi, Honghai Ji
Abstract
anti-inflammatory in vitro. The results show that the coating has good physical characterization, and Zn is uniformly bound to the surface of titanium and shows stable release and good biocompatibility to BMSCs, downregulating the expression of inflammation-related genes promoting the bone formation of BMSCs. We have successfully prepared zinc-coated micro-arc titanium oxide coating on the titanium surface, which has good osteogenesis and great anti-inflammatory potential and provides a new way for osseointegration in the implant.
Topics & Concepts
BiocompatibilityOsseointegrationCoatingTitaniumAlkaline phosphataseProinflammatory cytokineChemistryScanning electron microscopeMaterials scienceOsteocalcinQuartz crystal microbalanceInflammationImplantNanotechnologyBiochemistryMetallurgyImmunologyAdsorptionMedicineComposite materialSurgeryEnzymeOrganic chemistryBone Tissue Engineering MaterialsOrthopaedic implants and arthroplastyNanoparticles: synthesis and applications