Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors
Fabian P. Suchy, Daiki Karigane, Yusuke Nakauchi, Maimi Higuchi, Jinyu Zhang, Katja Pekrun, Ian Hsu, Amy C. Fan, Toshinobu Nishimura, Carsten T. Charlesworth, Joydeep Bhadury, T. Nishimura, Adam C. Wilkinson, Mark A. Kay, Ravindra Majeti, Hiromitsu Nakauchi
Topics & Concepts
BiologyCRISPRTransduction (biophysics)GenomeCas9Viral vectorComputational biologyInduced pluripotent stem cellGeneGeneticsGenome editingEmbryonic stem cellRecombinant DNABiochemistryCRISPR and Genetic EngineeringVirus-based gene therapy researchAnimal Genetics and Reproduction