Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents
Prasanta Das, Sarah Boone, Dipanwita Mitra, Lindsay Turner, Ritesh Tandon, Dražen Raucher, Ashton T. Hamme
Abstract
= 36 to 80 μM. The synthetic efficacy and biological relevance offer an opportunity to further drug-discovery development of fluoro-spiro-isoxazolines as novel anti-viral and anti-cancer agents.
Topics & Concepts
Combinatorial chemistryChemistryCancerStereochemistryVirologyBiologyMedicineInternal medicineFluorine in Organic ChemistryClick Chemistry and ApplicationsSynthesis and Biological Evaluation