Genetically Engineered MRI-Trackable Extracellular Vesicles as SARS-CoV-2 Mimetics for Mapping ACE2 Binding <i>In Vivo</i>
Andrea Gálisová, Jiří Zahradník, Hyla Allouche‐Arnon, Mattia I. Morandi, Paula Abou Karam, Michal Fisler, Ori Avinoam, Neta Regev‐Rudzki, Gideon Schreiber, Amnon Bar‐Shir
Abstract
can be modified to display mutants of the RBD of SARS-CoV-2, allowing rapid screening of currently raised or predicted variants of the virus. The proposed platform thus shows relevance and cruciality in the examination of quickly evolving pathogenic viruses in an adjustable, fast, and safe manner. Relying on MRI for visualization, the presented approach could be considered in the future to map ligand-receptor binding events in deep tissues, which are not accessible to luminescence-based imaging.
Topics & Concepts
MutagenesisExtracellular vesiclesComputational biologyBiophysicsIn vivoSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)BiologyVirusCell biologyMutantNanotechnologyChemistryVirologyMaterials scienceBiochemistryGeneticsGeneMedicineDiseasePathologyInfectious disease (medical specialty)Extracellular vesicles in diseaseSARS-CoV-2 and COVID-19 Researchinterferon and immune responses