Chetomin, a Hsp90/HIF1α pathway inhibitor, effectively targets lung cancer stem cells and non-stem cells
Shengping Min, Xiaoxu Wang, Qianyu Du, Huiyuan Gong, Yan Yang, Tao Wang, Nan Wu, Xincheng Liu, Wei Li, Chengling Zhao, Yuanbing Shen, Yuqing Chen, Xiaojing Wang
Abstract
lung cancer model, flank xenograft models, and a tumor propagation flank implanted model at doses that did not produce an observable toxicity to the animals. Chetomin blocked Hsp90/HIF1α pathway activity via inhibiting the Hsp90-HIF1α binding interaction without affecting Hsp90 or Hsp70 protein levels. This study advocates chetomin as a Hsp90/HIF1α pathway inhibitor and a potent, nontoxic NSCLC CSC-targeting molecule.
Topics & Concepts
Hsp90 inhibitorHsp90Cancer researchCancer stem cellStem cellHeat shock proteinLung cancerCancer cellBiologyCancerMedicinePathologyCell biologyBiochemistryGeneGeneticsHeat shock proteins researchPhysiological and biochemical adaptationsPlant Genetic and Mutation Studies