Ehrlichia chaffeensis TRP120 Is a Wnt Ligand Mimetic That Interacts with Wnt Receptors and Contains a Novel Repetitive Short Linear Motif That Activates Wnt Signaling
Madison Rogan, LaNisha L. Patterson, Caitlan D. Byerly, Tian Luo, Slobodan Paessler, Veljko Veljković, Bethany R. Quade, Jere W. McBride
Abstract
Upon infecting mammalian hosts, Ehrlichia chaffeensis establishes a replicative niche in microbe-eating immune system cells where it expertly orchestrates infection and spread. One of the ways Ehrlichia survives within these phagocytes is by activating evolutionarily conserved signaling pathways including the Wnt pathway; however, the molecular details of pathway hijacking have not been defined.
Topics & Concepts
Wnt signaling pathwayEhrlichia chaffeensisBiologyEhrlichiaCell biologyReceptorSignal transductionImmune systemVirologyGeneticsTickToxin Mechanisms and ImmunotoxinsIon Channels and ReceptorsEndoplasmic Reticulum Stress and Disease