The Role of Poly(ADP-ribose) Polymerase 1 in Nuclear and Mitochondrial Base Excision Repair
Geoffrey K. Herrmann, Y. Whitney Yin
Abstract
Poly(ADP-ribose) (PAR) Polymerase 1 (PARP-1), also known as ADP-ribosyl transferase with diphtheria toxin homology 1 (ARTD-1), is a critical player in DNA damage repair, during which it catalyzes the ADP ribosylation of self and target enzymes. While the nuclear localization of PARP-1 has been well established, recent studies also suggest its mitochondrial localization. In this review, we summarize the differences between mitochondrial and nuclear Base Excision Repair (BER) pathways, the involvement of PARP-1 in mitochondrial and nuclear BER, and its functional interplay with other BER enzymes.
Topics & Concepts
Poly ADP ribose polymerasePolymeraseBase excision repairDNA repairBiologyMolecular biologyMitochondrial DNANucleotide excision repairEnzymeGeneticsBiochemistryDNAGenePARP inhibition in cancer therapyDNA Repair MechanismsToxin Mechanisms and Immunotoxins