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Oridonin promotes RSL3-induced ferroptosis in breast cancer cells by regulating the oxidative stress signaling pathway JNK/Nrf2/HO-1

Shiying Ye, Xiangyan Hu, Shaowei Sun, Bo Su, Jiye Cai, Jinhuan Jiang

2024European Journal of Pharmacology30 citationsDOI

Topics & Concepts

Oxidative stressCancer researchReactive oxygen speciesApoptosisGPX4Programmed cell deathBreast cancerSuperoxide dismutaseGlutathione peroxidaseMalondialdehydeCancerGlutathioneCancer cellLipid peroxidePharmacologyChemistryBiologyMedicineInternal medicineBiochemistryEnzymeFerroptosis and cancer prognosisCancer, Lipids, and MetabolismDrug Transport and Resistance Mechanisms
Oridonin promotes RSL3-induced ferroptosis in breast cancer cells by regulating the oxidative stress signaling pathway JNK/Nrf2/HO-1 | Litcius