Diverse privileged <i>N</i>-polycyclic skeletons accessed from a metal-free cascade cyclization reaction
Wenzhong Li, Yu Wang, Huijing Qi, Ran Shi, Jiazhu Li, Si Chen, Xin‐Ming Xu, Weili Wang
Abstract
Metal-free cascade cyclization of 2-acylbenzoic acids with amines provided a one-pot synthesis of diverse isoindoloisoquinoline and benzoindolizinoindole derivatives, which were subsequently used to produce nitrogen-containing nine-membered ring compounds.
Topics & Concepts
ChemistryCombinatorial chemistryRing (chemistry)CascadeMetalCatalysisSubstrate (aquarium)Cascade reactionOrganic chemistryNanotechnologyMaterials scienceOceanographyGeologyChromatographySynthesis and pharmacology of benzodiazepine derivativesCatalytic C–H Functionalization MethodsSynthetic Organic Chemistry Methods