I<sub>2</sub>-Promoted site-selective C–C bond cleavage of aryl methyl ketones as C1 synthons for constructing 5-acyl-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridines
You Zhou, Li‐Sheng Wang, Shuang‐Gui Lei, Yunxiang Gao, Jin‐Tian Ma, Zhi‐Cheng Yu, Yan‐Dong Wu, An‐Xin Wu
Abstract
A novel iodine promoted [1 + 3 + 2] cleavage cyclization reaction for the synthesis of 1 H -pyrazolo[3,4- b ]pyridines from aryl methyl ketones, 5-aminopyrazoles and enaminones has been established.
Topics & Concepts
ChemistrySynthonArylCleavage (geology)Bond cleavageMedicinal chemistryStereochemistryIodineOrganic chemistryCatalysisAlkylFracture (geology)EngineeringGeotechnical engineeringCatalytic C–H Functionalization MethodsSynthesis and Characterization of PyrrolesSulfur-Based Synthesis Techniques