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Discovery of heterocycle-containing α-naphthoflavone derivatives as water-soluble, highly potent and selective CYP1B1 inhibitors

Jinyun Dong, G. Huang, Qing Cui, Qingqing Meng, Shaoshun Li, Jiahua Cui

2020European Journal of Medicinal Chemistry31 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryIC50CYP1B1Cytochrome P450StereochemistryLead compoundActive siteCombinatorial chemistryEnzymeBiochemistryIn vitroSynthesis and biological activityPharmacogenetics and Drug MetabolismInflammatory mediators and NSAID effects
Discovery of heterocycle-containing α-naphthoflavone derivatives as water-soluble, highly potent and selective CYP1B1 inhibitors | Litcius