Synthesis of <i>N</i>‐Fused Seven‐Membered Indoline‐3‐ones <i>via</i> a Palladium‐Catalyzed One‐Pot Insertion Reaction from 2‐Alkynyl Arylazides and Cyclic <i>β</i>‐Diketones
Ping Li, Rong Sheng, Zhiqiang Zhou, Guiwen Hu, Xiaoxiang Zhang
Abstract
A novel strategy to synthesize N ‐fused seven‐membered multifunctional polycyclic indoline‐3‐one derivatives via insertion of cyclic C ‐acylimines into cyclic β ‐diketones has been described. The reaction proceeded well under mild reaction conditions via a one‐pot, three‐steps method, which has shown good tolerance of various functional groups.
Topics & Concepts
IndolineChemistryPalladiumCatalysisReaction conditionsInsertion reactionCombinatorial chemistryOrganic chemistryMedicinal chemistryCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsSynthesis of Indole Derivatives