Side effects of drug treatments for gastro-oesophageal reflux disease: current controversies
Anjan Dhar, Frances Maw, Helen Dallal, Stephen Attwood
Abstract
The two main drugs used in the treatment of gastro-oesophageal reflux disease are proton pump inhibitors and histamine-2 receptor antagonists and both these agents have been implicated in a number of adverse effects, leading to considerable controversies related to their long-term use. This paper is aimed at a critical review of the published literature and the clinical significance of these reported side effects, most of which are associations rather than causal.
Topics & Concepts
MedicineRefluxGastro-DiseaseDrugAdverse effectIntensive care medicineHistamine H2 receptorHistamineProton-pump inhibitorInternal medicineGastroenterologyPharmacologyReceptorAntagonistGastroesophageal reflux and treatmentsHelicobacter pylori-related gastroenterology studiesEosinophilic Esophagitis