A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus
Boaz E. Aronson, Laurianne Scourzic, Veevek Shah, Emily Swanzey, Andreas Kloetgen, Alexander Polyzos, Abhishek Sinha, Annabel Azziz, Inbal Caspi, Jiexi Li, Bobbie Pelham‐Webb, Rachel A. Glenn, Thomas Vierbuchen, Hynek Wichterle, Aristotelis Tsirigos, Meelad M. Dawlaty, Matthias Stadtfeld, Effie Apostolou
Topics & Concepts
BiologyImprinting (psychology)Genomic imprintingGeneticsEpigeneticsDNA methylationAlleleChromatinEnhancerLocus (genetics)GenePhenotypeMethylationGene expressionEpigenetics and DNA MethylationGenetic Syndromes and ImprintingRNA modifications and cancer