Faster sperm selected by rheotaxis leads to superior early embryonic development <i>in vitro</i>
Mohammad Yaghoobi, Abdallah W. Abdelhady, Amirhossein Favakeh, Philip Xie, Stephanie Cheung, Amir Mokhtare, Yoke Lee Lee, Ann V. Nguyen, Gianpiero D. Palermo, Zev Rosenwaks, Soon Hon Cheong, Alireza Abbaspourrad
Abstract
) were used for fertilization and compared to sperm sorted by centrifugation. The samples collected at the highest flow rate resulted in the formation of 23% more blastocysts compared to the control. While selecting for higher quality sperm by increasing the flow rate does result in lower sperm yield, quality improvement and yield may be balanced by better embryonic development.
Topics & Concepts
SpermEmbryogenesisAndrologyReproductive tractEmbryonic stem cellCell biologyBiologyAnatomyEmbryoMedicineEndocrinologyGeneticsGeneReproductive Biology and FertilityMicrofluidic and Bio-sensing TechnologiesSperm and Testicular Function