Mechanistic insights into the C<sub>55</sub>-P targeting lipopeptide antibiotics revealed by structure–activity studies and high-resolution crystal structures
Thomas M. Wood, Matthieu R. Zeronian, Ned Buijs, Kristine Bertheussen, Hanieh K. Abedian, Aidan V. Johnson, Nicholas M. Pearce, Martin Lutz, Johan Kemmink, Tjalling Seirsma, Leendert W. Hamoen, B.J.C. Janssen, Nathaniel I. Martin
Abstract
-P targeting CDAs highlighting their unique mechanism of action relative to the clinically used CDA daptomycin.
Topics & Concepts
LipopeptideAntibioticsResolution (logic)ChemistryStereochemistryBiologyBiochemistryBacteriaComputer scienceGeneticsArtificial intelligenceFullerene Chemistry and ApplicationsBoron and Carbon Nanomaterials ResearchMetal and Thin Film Mechanics